SARS-CoV-2 Mpro-IN-50

SARS-CoV-2 Mpro-IN-50 (Compound 30) is a noncovalent SARS-CoV-2 Mpro inhibitor with an IC50 of 14 nM. SARS-CoV-2 Mpro-IN-50 is also a pan-CoV Mpro inhibitor with IC50 s of 20-190 nM for SARS-CoV-1 Mpro, 229E Mpro, HKU1 Mpro, MERS Mpro, NL63 Mpro and OC43 Mpro. SARS-CoV-2 Mpro-IN-50 has significant antiviral activity against the SARS-CoV-2 omicron variant (EC50 : 22 nM) . SARS-CoV-2 Mpro-IN-50 can be used for coronavirus infections research[1].

Product Specifications

CAS Number

[3038701-72-0]

UNSPSC

12352005

Target

SARS-CoV

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

FC1=CC([C@H]2[C@H](NC([C@H](NC(C(F)(F)F)=O)C(C)C)=O)CN(C(C3=NC=CN4C3=CN=C4)=O)CC2)=CC(F)=C1

Molecular Formula

C25H25F5N6O3

Molecular Weight

552.50

References & Citations

[1]Okabe A, et al. Discovery of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 Main Protease through Computer-Aided Drug Design. J Med Chem. 2025 Oct 23;68 (20) :21330-21345.