DEL1187-126-28-16

DEL1187-126-28-16 is a JAK3 inhibitor with IC50s of 10 and 0.97 nM against JAK3 WT in 0 and 60 min. DEL1187-126-28-16 has no activity at all towards the C909S mutant, JAK1, JAK2, and TYK2. DEL1187-126-28-16 can be used for the study of immune-mediated diseases[1].

Product Specifications

UNSPSC

12352005

Target

JAK

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Inflammation/Immunology

Smiles

CNC(CC1=CC=C(C=C1)NC2=NC=NC(NCC3=CC=CC(CNC(CCl)=O)=C3)=N2)=O

Molecular Formula

C22H24ClN7O2

Molecular Weight

453.92

References & Citations

[1]Chen T, et al. Deep seeking covalent DNA encoded library for novel JAK3 inhibitor discovery. Bioorg Med Chem. 2025 Oct 17;132:118448.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

JAK3

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