PGK1-IN-1
PGK1-IN-1 (Compound 6e) is a potent and selective PGK1 inhibitor (IC50: 33 nM). PGK1-IN-1 inhibits PGK1-mediated glycolytic metabolism and reduces glucose consumption/lactate production. PGK1-IN-1 enhances Nrf2 accumulation and HO-1 expression, and suppresses the transcription and protein levels of the inflammatory cytokines IL-1β and IL-6. PGK1-IN-1 ameliorates Dextran sulfate sodium (DSS) -induced experimental colitis in mice. PGK1-IN-1 can be used for research of inflammatory bowel disease (IBD).
Product Specifications
CAS Number
3093312-81-0
UNSPSC
12352005
Target
Phosphoglycerate Kinase (PGK)
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
COC1=CC(NC(N=C(N[C@H]2CC[C@@H](CC2)O)N=C34)=C4N=CN3C5CC5)=CC(OC)=C1
Molecular Formula
C22H28N6O3
Molecular Weight
424.50
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PGK1
Frequently Asked Questions
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