TGF-8027
TGF-8027 is a selective 5-HT2A agonist that can cross the blood-brain barrier. TGF-8027 exhibits EC50s of 3.3 nM, 160 nM and 7600 nM against human 5-HT2A, 5-HT2C and 5-HT2B and exhibits EC50s against mouse 5-HT2A and mouse 5-HT2C of 14 and 210 nM. TGF-8027 can induce a head-shaking response in mice. TGF-8027 can be used to study diseases that target the 5-HT2A receptor (such as depression) [1].
Product Specifications
UNSPSC
12352005
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
COC1=C(CCNC(C)C2=CC=CC=C2O)C=C(OC)C(C#N)=C1
Molecular Formula
C19H22N2O3
Molecular Weight
326.39
References & Citations
[1]Fenske TG, et al. Discovery of Highly Selective 5-HT2A Agonists Using Structure-Guided Design. J Med Chem. 2025 Oct 9;68 (19) :20619-20635.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor
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