DEL1187-126-5-80
DEL1187-126-5-80 is a JAK3 inhibitor with IC50s of 52 and 7.9 nM against JAK3 WT in 0 and 60 min. DEL1187-126-5-80 has no activity at all towards the C909S mutant, JAK1, JAK2, and TYK2. DEL1187-126-5-80 can be used for the study of immune-mediated diseases[1].
Product Specifications
UNSPSC
12352005
Target
JAK
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Smiles
C#CC(NCC1CCCN(C1)C2=NC(NC3=CC=C(C=C3)CC(NC)=O)=NC=N2)=O
Molecular Formula
C21H25N7O2
Molecular Weight
407.47
References & Citations
[1]Chen T, et al. Deep seeking covalent DNA encoded library for novel JAK3 inhibitor discovery. Bioorg Med Chem. 2025 Oct 17;132:118448.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK3
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