PKM2-IN-12

PKM2-IN-12 is an orally active PKM2 inhibitor with an IC50 of 10 nM. PKM2-IN-12 inhibits COLO-205 cell proliferation and migration, arrests the cell cycle, and induces apoptosis. PKM2-IN-12 significantly reduces cellular levels of lactate, pyruvate, and ROS. PKM2-IN-12 directly kills cancer cells and restores disrupted gut microbiota balance in mice model. PKM2-IN-12 can be used to study colorectal cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Endogenous Metabolite; Pyruvate Kinase; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(C1=C(C2=CC=C(Cl)C=C2)N=C(NC3=CC=C(Cl)C=C3)S1)C4=CN=C5C=CC=CN54

Molecular Formula

C23H14Cl2N4OS

Molecular Weight

465.35

References & Citations

[1]Ghosh Chowdhury M, et al. Thiazole-Based Tumor Pyruvate Kinase M2 Inhibitors: A Paradigm-Shifting Therapeutic Strategy Targeting Metabolic and Microbial Synergy in Colorectal Cancer. J Med Chem. 2025 Oct 23;68 (20) :21786-21806.