GI261520A
GI261520A is a egfr/erbb2 dual inhibitor. GI261520A inhibits PhoQ phosphorylation dose-dependently. GI261520A can downregulate the activity levels of PhoP/PhoQ. GI261520A inhibits pagC reporter expression levels with an IC50 of 3.2 μM. GI261520A inhibits PhoQc autokinase activtiy by 80%. GI261520A can permeate the eukaryotic plasmatic and vascular cell membranes and reach intravacuolar Salmonella to block intramacrophage proliferation[1].
Product Specifications
CAS Number
179248-64-7
UNSPSC
12352005
Target
Bacterial; EGFR
Related Pathways
Anti-infection; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Infection
Smiles
COC1=CC2=C(NC3=CC=C(C=C3)OCC4=CC=CC=C4)N=CN=C2C=C1
Molecular Formula
C22H19N3O2
Molecular Weight
357.41
References & Citations
[1]Carabajal MA, et al., Quinazoline-Based Antivirulence Compounds Selectively Target Salmonella PhoP/PhoQ Signal Transduction System. Antimicrob Agents Chemother. 2019 Dec 20;64 (1) :e01744-19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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