GI261520A

GI261520A is a egfr/erbb2 dual inhibitor. GI261520A inhibits PhoQ phosphorylation dose-dependently. GI261520A can downregulate the activity levels of PhoP/PhoQ. GI261520A inhibits pagC reporter expression levels with an IC50 of 3.2 μM. GI261520A inhibits PhoQc autokinase activtiy by 80%. GI261520A can permeate the eukaryotic plasmatic and vascular cell membranes and reach intravacuolar Salmonella to block intramacrophage proliferation[1].

Product Specifications

CAS Number

[179248-64-7]

UNSPSC

12352005

Target

Bacterial; EGFR

Related Pathways

Anti-infection; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Infection

Smiles

COC1=CC2=C(NC3=CC=C(C=C3)OCC4=CC=CC=C4)N=CN=C2C=C1

Molecular Formula

C22H19N3O2

Molecular Weight

357.41

References & Citations

[1]Carabajal MA, et al., Quinazoline-Based Antivirulence Compounds Selectively Target Salmonella PhoP/PhoQ Signal Transduction System. Antimicrob Agents Chemother. 2019 Dec 20;64 (1) :e01744-19.