A-1592668
A-1592668 is a selective CDK9 inhibitor. A-1592668 induces Apoptosis. A-1592668 plus Venetoclax (HY-15531) co-treatment inhibits the growth of Jeko-1 tumors[1].
Product Specifications
CAS Number
[1628314-13-5]
UNSPSC
12352005
Target
Apoptosis; CDK
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
FC1=CN=C(NC(C2=CCN([C@@H]3CC[C@H](CC3)C(O)=O)CC2)=C4)C4=C1C5=C(C=CC(F)=C5)OC
Molecular Formula
C26H27F2N3O3
Molecular Weight
467.51
References & Citations
[1]Zhao X, et al. Inhibition of cyclin-dependent kinase 9 synergistically enhances venetoclax activity in mantle cell lymphoma. EJHaem. 2020 Aug 4;1 (1) :161-169.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-178733/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9
Curated Selection
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