AB-22

AB-22, a vinyl sulfate compound, is an orally active antifungal agent. AB-22 inhibits hyphal growth and biofilm initiation by inhibiting the gene expression of ALS3, HWP1, and ECE1 in Candida albicans SC5314 cells. AB-22 can be used for the research of infrction, such as systemic candidiasis[1].

Product Specifications

CAS Number

[1463913-43-0]

UNSPSC

12352005

Target

Acetolactate Synthase (ALS) ; Endothelin-Converting Enzyme (ECE) ; Fungal

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

O=C(NN(CCO)C1=CC(C(C)C)=C(C(C)=NN2C)C2=N1)NC3=CC(OCCC)=NC(Cl)=C3

Molecular Formula

C22H30ClN7O3

Molecular Weight

475.97

References & Citations

[1]Lee KT, et al. The novel antifungal agent AB-22 displays in vitro activity against hyphal growth and biofilm formation in Candida albicans and potency for treating systemic candidiasis. J Microbiol. 2022;60 (4) :438-443.