AMG-315
AMG-315 is a selective and potent CB1 agonist with a Ki of 7.8 nM and an EC50 of 0.6 nM. AMG-315 can significantly inhibit the cAMP production induced by Forskolin with the maximum inhibitory effect reaching 76%. AMG-315 has significant stability against all endogenous cannabinoid hydrolases and oxidases. AMG-315 increases the mechanical withdrawal threshold in CFA (HY-153808) -induced inflammatory pain model. AMG-315 can be used for the research of inflammation[1].
Product Specifications
CAS Number
2244425-65-6
UNSPSC
12352211
Target
Cannabinoid Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Inflammation/Immunology
Smiles
CCCCC/C=C\[C@H](C)/C=C\C/C=C\C/C=C\CCCC(N[C@H](C)CO)=O
Molecular Formula
C24H41NO2
Molecular Weight
375.59
References & Citations
[1]Liu Y, et al. (R) -N- (1-Methyl-2-hydroxyethyl) -13- (S) -methyl-arachidonamide (AMG315) : a novel chiral potent endocannabinoid ligand with stability to metabolizing enzymes[J]. Journal of medicinal chemistry, 2018, 61 (19) : 8639-8657.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CB1
Frequently Asked Questions
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