Lithocholic amide-C2-N (didecane)

Lithocholic amide-C2-N (didecane) (Compound LC10) is a Lithocholic acid (HY-B0172) analogue. Lithocholic amide-C2-N (didecane) can form lipid nanoparticles spontaneously in the aqueous milieu, permeate through the skin, penetrate the deeper dermal layers, and exert anti-inflammatory effects against psoriasis-like chronic skin inflammations. Lithocholic amide-C2-N (didecane) can inhibit abnormal proliferation of keratinocytes, downregulate the mRNA expression of the psoriasis-associated receptor EphA2 and reduce serum levels of multiple pro-inflammatory factors such as IL-1α, IL-1β, and IFN-γ by inhibiting activation of the Th17/Th2 inflammatory pathway[1].

Product Specifications

CAS Number

[2768690-22-6]

UNSPSC

12352005

Target

Drug Derivative; Ephrin Receptor; IFNAR; Interleukin Related

Related Pathways

Immunology/Inflammation; Others; Protein Tyrosine Kinase/RTK

Field of Research

Inflammation/Immunology

Smiles

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NCCN(CCCCCCCCCC)CCCCCCCCCC)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C

Molecular Formula

C46H86N2O2

Molecular Weight

699.19

References & Citations

[1]Rachamalla HK, et al. Skin-Permeable Nano-Lithocholic Lipidoid Efficiently Alleviates Psoriasis-like Chronic Skin Inflammations. ACS Appl Mater Interfaces. 2022 Apr 6;14 (13) :14859-14870.