WML-01

WML-01 is a fungicide with EC50s of 0.079, 0.72 and 2.02 μg/mL against F. graminearum, F. fujikuroi and S. sclerotiorum. WML-01 disrupts the cell membrane of F. graminearum and induces deposition of lipid droplets. WML-01 inhibits Deoxynivalenol (DON) biosynthesis with no cross-resistance and strongly suppresses ribosomal subunit assembly, impairing protein synthesis. WML-01 effectively controls the fusarium head blight (FHB) epidemic[1].

Product Specifications

CAS Number

3057478-36-8

UNSPSC

12352005

Target

Fungal

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

CC1=C(C(OC12CCCCC2)=O)/C(C)=C3SC(NC/3=O)=S

Molecular Formula

C15H17NO3S2

Molecular Weight

323.43

References & Citations

[1]Li Y, et al. Discovery of WML-01, a Spirocyclic Butenolide Derivative Featuring a Rhodanine Motif, Exhibiting High Fungicidal Activity against Fusarium Species. J Agric Food Chem. 2025 Oct 15;73 (41) :25805-25812.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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