PTPN2/1-IN-4
PTPN2/1-IN-4 (Compound WS35) is an orally active, dual-functional inhibitor of PTPN1 and PTPN2 with IC50s of 12.8 and 5.8 nM for PTPN1 and PTPN2, respectively. PTPN2/1-IN-4 modulates the IFNγ-JAK-STAT signaling pathway and significantly augments CD8+ T-cell tumor infiltration. PTPN2/1-IN-4 has potent anticancer activity, robustly inhibiting tumor growth both as a monotherapy and in combination with an anti-PD-1 antibody in B16-OVA syngeneic mouse models[1].
Product Specifications
CAS Number
3093350-55-8
UNSPSC
12352005
Target
IFNAR; JAK; Phosphatase; STAT
Related Pathways
Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
FC1=C(C(O)=CC(C2=CN=C(C(C)=C2)NCCC(C)C)=C1)N3CC(NS3(=O)=O)=O
Molecular Formula
C19H23FN4O4S
Molecular Weight
422.47
References & Citations
[1]Wang D, et al. Development of Novel PTPN2/1 Inhibitors for the Treatment of Melanoma. J Med Chem. 2025 Oct 23;68 (20) :21917-21938.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT1
Frequently Asked Questions
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