JNJ627
JNJ627 is a small molecule allosteric inhibitor of IL-17A with a KD of 92 nM. JNJ627 effectively inhibits the binding of IL-17A and IL-17RA, with an IC50 value of 16 nM. JNJ627 is capable of inhibiting the secretion of G-CSF (granulocyte colony-stimulating factor) caused by IL-17A stimulation. JNJ627 can be used for the study of autoimmune diseases (such as psoriasis) [1].
Product Specifications
UNSPSC
12352005
Target
Interleukin Related
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CC1(SCCN[C@H]1C(NCC2=CC=CC(C(N[C@@H](C3CCCCC3)C(NC4=CC=CC=C4)=O)=O)=C2)=O)C
Molecular Formula
C29H38N4O3S
Molecular Weight
522.70
References & Citations
[1]Milla ME, et al. A Novel Small Molecule Allosteric Inhibitor of IL-17A from a DNA-Encoded Library. ACS Medicinal Chemistry Letters. 2025 Oct 6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-17
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