E3 Ligase Ligand-linker Conjugate 216
E3 Ligase Ligand-linker Conjugate 216 is a conjugate of an E3 ligase CRBN ligand and a linker. E3 Ligase Ligand-linker Conjugate 216 can be used to synthesize PROTAC SARS-CoV-2 RdRp Degrader-1. PROTAC SARS-CoV-2 RdRp Degrader-1 is a SARS-CoV-2 RdRp PROTAC degrader[1].
Product Specifications
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Infection
Smiles
O=C1CC[C@@H](C(N1)=O)N2C(C3=C(C2=O)C=CC(OCCC4=CN(N=N4)CCCCCC(O)=O)=C3)=O
Molecular Formula
C23H25N5O7
Molecular Weight
483.47
References & Citations
[1]Shehzadi K, et al. Structure-Informed Design of High-Cooperativity PROTAC Targeting SARS-CoV-2 RdRp via Click Chemistry and Enhanced Sampling Simulations. J Med Chem. 2025 Nov 13;68 (21) :23247-23266.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
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