MyD88-IN-4

MyD88-IN-4 is a MyD88 inhibitor. MyD88-IN-4 exerts antiviral effects by up-regulating IFN-β, and anti-inflammatory effects by inhibiting pro-inflammatory cytokine production. MyD88-IN-4 prevents MyD88 homodimer formation and its interaction with IRF3/IRF7. MyD88-IN-4 demonstrates efficacy against encephalitic alphavirus infections by reducing viral replication and improving survival in VEEV TC-83-infected mouse models. MyD88-IN-4 can be used for the study of alphavirus infections, bacterial toxin-related diseases, and sepsis[1].

Product Specifications

CAS Number

[1801552-15-7]

UNSPSC

12352005

Target

IFNAR; MyD88

Related Pathways

Immunology/Inflammation

Field of Research

Infection; Inflammation/Immunology

Smiles

O=C(N1CCCC1)[C@H](C(C)C)N(CCCC2=CC=CC=C2)C([C@@H]3CC[C@H](CC3)C(N(CCCC4=CC=CC=C4)[C@@H](C(C)C)C(N5CCCC5)=O)=O)=O

Molecular Formula

C44H64N4O4

Molecular Weight

713.00

References & Citations

[1]Saikh, K. U., et al. A Small Molecule Inhibitor of MyD88 for Therapeutic Treatment Against Alphavirus and Staphylococcal Enterotoxin Infections and Toxin Exposure. International Publication No.: WO 2015/191111 A2. World Intellectual Property Organization (WIPO) . 17 December 2015.