BAS00602705
BAS00602705 is an E-cadherin inhibitor. BAS00602705 exerts its function by blocking the trans-interactions of E-cadherin molecules within junctional complexes, without permanently altering E-cadherin expression levels. BAS00602705 significantly impairs invadopodia formation in pancreatic cancer cells. BAS00602705 can be used for the study of anti-invasive therapeutic strategies in cancers characterized by dysregulated E-cadherin-mediated invadopodia activity, such as pancreatic ductal adenocarcinoma (PDAC) [1].
Product Specifications
CAS Number
[317321-89-4]
UNSPSC
12352005
Target
Cadherin
Related Pathways
Cytoskeleton
Field of Research
Cancer
Smiles
O=C(NC(CC1=CNC2=C1C=CC=C2)C(NC3=CC=C(C=C3)Br)=O)OCC4=CC=CC=C4
Molecular Formula
C25H22BrN3O3
Molecular Weight
492.36
References & Citations
[1]Dobric A, et al. E-Cadherin Is a Structuring Component of Invadopodia in Pancreatic Cancer. J Cell Mol Med. 2025 May;29 (9) :e70608.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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