Thalidomide-C1-O-CO-C2-Piperazine-CO-C1-Azacyclohexane-C1-Piperazine

Thalidomide-C1-O-CO-C2-Piperazine-CO-C1-Azacyclohexane-C1-Piperazine is an E3 ligase ligand-linker conjugate containing a cereblon (CRBN) ligand for E3 ubiquitin ligase and a linker. Thalidomide-C1-O-CO-C2-Piperazine-CO-C1-Azacyclohexane-C1-Piperazine can be used to synthesize PROTAC CDK4/6/9 degrader 2 (HY-178516) [1].

Product Specifications

UNSPSC

12352005

Target

E1/E2/E3 Enzyme; E3 Ligase Ligand-Linker Conjugates

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CCC(OCN1C(C(CCC1=O)N(C2=O)C(C(C=C3)=C2C=C3N(CC4)CCN4C(CN(CC5)CCC5CN(CC6)CCN6C(OC(C)(C)C)=O)=O)=O)=O)=O

Molecular Formula

C38H53N7O9

Molecular Weight

751.87

References & Citations

[1]Hu H, et al. Translational Research on the Oral Delivery of the Cytotoxic PROTAC Molecule via Tumor-Targeting Prodrug Strategy for Triple-Negative Breast Cancer Treatment. J Med Chem. 2025 Oct 9;68 (19) :20464-20486.