Thalidomide-C1-O-CO-C11
Thalidomide-C1-O-CO-C11 is a ligand for E3 ubiquitin ligase. Thalidomide-C1-O-CO-C11 can be connected to Aurora-A ligand 1 (HY-168440) by a linker (HY-178512) to form PROTAC CDK4/6/9 degrader 2 (HY-178516) [1].
Product Specifications
UNSPSC
12352005
Target
E1/E2/E3 Enzyme; Ligands for E3 Ligase
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(CCCCCCCCCCC)OCN1C(C(CCC1=O)N(C2=O)C(C3=C2C=CC=C3)=O)=O
Molecular Formula
C26H34N2O6
Molecular Weight
470.56
References & Citations
[1]Hu H, et al. Translational Research on the Oral Delivery of the Cytotoxic PROTAC Molecule via Tumor-Targeting Prodrug Strategy for Triple-Negative Breast Cancer Treatment. J Med Chem. 2025 Oct 9;68 (19) :20464-20486.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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