PROTAC CDK4/6/9 degrader 2
PROTAC CDK4/6/9 degrader 2 (Compound P4) is a CDK4/6/9 PROTAC prodrug with oral activity and low toxicity. PROTAC CDK4/6/9 degrader 2 can significantly inhibit tumor growth and suppress tumor lung metastasis. PROTAC CDK4/6/9 degrader 2 can be used in the research of cancer such as breast cancer. (Pink: CDK4/6/9 Ligand ; Blue: CRBN Ligand (HY-178517) ; Black: Linker (HY-178512) )
Product Specifications
UNSPSC
12352005
Target
CDK; PROTACs
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Field of Research
Cancer
Smiles
O=C(N(C)C)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=CC=C(C=C4)C(CN5CCN(CC5)CC6CCN(CC6)CC(N7CCN(CC7)C8=CC9=C(C=C8)C(N(C9=O)C(C(N%10COC(CCCCCCCCCCC)=O)=O)CCC%10=O)=O)=O)=O
Molecular Formula
C64H86N12O9
Molecular Weight
1167.44
References & Citations
[1]Hu H, et al. Translational Research on the Oral Delivery of the Cytotoxic PROTAC Molecule via Tumor-Targeting Prodrug Strategy for Triple-Negative Breast Cancer Treatment. J Med Chem. 2025 Oct 9;68 (19) :20464-20486.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4; CDK6; CDK9
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
SPNS2-8664M 50 µg
Recombinant Mouse SPNS2 Protein, His (Fc)-Avi-tagged
Sign In for Pricing
View Details 
abx257511 96 Tests
Human Undercarboxylated Matrix Gla Protein (ucMGP) ELISA Kit
Sign In for Pricing
View Details 
K0334506 1.0 µg DNA
C20orf90 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
Sign In for Pricing
View Details 
M2421-29D 50 µg
Matrix Metalloproteinase 3, Control Peptide (Mmp3, MMP-3, PTR1 Protein, Stromelysin-1, SL-1, Transin-1) discontinued
Sign In for Pricing
View Details