PROTAC CDK4/6/9 degrader 2

PROTAC CDK4/6/9 degrader 2 (Compound P4) is a CDK4/6/9 PROTAC prodrug with oral activity and low toxicity. PROTAC CDK4/6/9 degrader 2 can significantly inhibit tumor growth and suppress tumor lung metastasis. PROTAC CDK4/6/9 degrader 2 can be used in the research of cancer such as breast cancer. (Pink: CDK4/6/9 Ligand (HY-168440) ; Blue: CRBN Ligand (HY-178517) ; Black: Linker (HY-178512) ) [1]

Product Specifications

UNSPSC

12352005

Target

CDK; PROTACs

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Field of Research

Cancer

Smiles

O=C(N(C)C)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=CC=C(C=C4)C(CN5CCN(CC5)CC6CCN(CC6)CC(N7CCN(CC7)C8=CC9=C(C=C8)C(N(C9=O)C(C(N%10COC(CCCCCCCCCCC)=O)=O)CCC%10=O)=O)=O)=O

Molecular Formula

C64H86N12O9

Molecular Weight

1167.44

References & Citations

[1]Hu H, et al. Translational Research on the Oral Delivery of the Cytotoxic PROTAC Molecule via Tumor-Targeting Prodrug Strategy for Triple-Negative Breast Cancer Treatment. J Med Chem. 2025 Oct 9;68 (19) :20464-20486.