Thalidomide-piperazine-CO-C-azacyclohexane-C1-piperazine

Thalidomide-piperazine-CO-C-azacyclohexane-C1-piperazine is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-piperazine-CO-C-azacyclohexane-C1-piperazine can be used for synthesizing PROTAC CDK4/6/9 degrader 1 (HY-178452) [1].

Product Specifications

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(C(CC1)N(C2=O)C(C(C2=C3)=CC=C3N(CC4)CCN4C(CN(CC5)CCC5CN(CC6)CCN6C(OC(C)(C)C)=O)=O)=O)NC1=O

Molecular Formula

C34H47N7O7

Molecular Weight

665.78

References & Citations

[1]Hu H, et al. Translational Research on the Oral Delivery of the Cytotoxic PROTAC Molecule via Tumor-Targeting Prodrug Strategy for Triple-Negative Breast Cancer Treatment. J Med Chem. 2025 Oct 9;68 (19) :20464-20486.