JQ1-S (GlcNAc) Cq
JQ1-S (GlcNAc) Cq is a sugar-coated BRD4 PROTAC degrader. JQ1-S (GlcNAc) Cq can inhibit the formation of the ternary complex between CRBN and BRD4 (BD1/BD2) . JQ1-S (GlcNAc) Cq can be used for the research of cancer[1]. (Structure Note: Pink: BRD4 ligand (HY-78695) ; Blue: CRBN ligand (HY-178514) ; Black: linker (HY-W105727) ; BRD4 ligand-Linker: (HY-178519) )
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Related Pathways
Epigenetics; PROTAC
Field of Research
Cancer
Smiles
O=C(N1)[C@@H](NC([C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(C)=O)NC(CCCCCCCCNC(C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C5=C(SC(C)=C5C)N6C3=NN=C6C)=O)=O)=O)CCC1=O
Molecular Formula
C44H58ClN9O11S
Molecular Weight
956.50
References & Citations
[1]Zhu Q, et al. Enzyme-Activated Sugar-Coated Bifunctional Degraders. J Am Chem Soc. 2025 Sep 24;147 (38) :34672-34680.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4; Cereblon
Curated Selection
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