TRPV4-KCa2.3 modulator 1
TRPV4-KCa2.3 modulator 1 (Compound IB-2) is a TRPV4-KCa2.3 protein complex enhancer with antihypertensive activity. TRPV4-KCa2.3 modulator 1 enhances endothelial cell hyperpolarization and vasodilatio. TRPV4-KCa2.3 modulator 1 is promising for research of hypertension and cardiovascular disorders[1].
Product Specifications
CAS Number
2616611-60-8
UNSPSC
12352005
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Cardiovascular Disease
Smiles
O=C(NCCCCCNC(C1=CC=C(C=C1)F)=O)NC2=CC=C(CN3CCN(CC3)CC)C=C2
Molecular Formula
C26H36FN5O2
Molecular Weight
469.59
References & Citations
[1]Yang S, et al. Design, synthesis, and biological evaluation of TRPV4-KCa2. 3 coupling enhancers as novel therapeutic agents for hypertension[J]. European Journal of Medicinal Chemistry, 2025: 117724.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPV4
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