TRPV4-KCa2.3 modulator 1

TRPV4-KCa2.3 modulator 1 (Compound IB-2) is a TRPV4-KCa2.3 protein complex enhancer with antihypertensive activity. TRPV4-KCa2.3 modulator 1 enhances endothelial cell hyperpolarization and vasodilatio. TRPV4-KCa2.3 modulator 1 is promising for research of hypertension and cardiovascular disorders[1].

Product Specifications

CAS Number

[2616611-60-8]

UNSPSC

12352005

Target

TRP Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Cardiovascular Disease

Smiles

O=C(NCCCCCNC(C1=CC=C(C=C1)F)=O)NC2=CC=C(CN3CCN(CC3)CC)C=C2

Molecular Formula

C26H36FN5O2

Molecular Weight

469.59

References & Citations

[1]Yang S, et al. Design, synthesis, and biological evaluation of TRPV4-KCa2. 3 coupling enhancers as novel therapeutic agents for hypertension[J]. European Journal of Medicinal Chemistry, 2025: 117724.