MPGES1-IN-10
MPGES1-IN-10 (Compound 7d) is a potent microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor with an IC50 value of 1.0 μM. mPGES1-IN-10 is promising for research of chronic inflammation-related diseases and malignancies such as colorectal cancer[1].
Product Specifications
UNSPSC
12352005
Target
PGE synthase
Related Pathways
Immunology/Inflammation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C1C2=CC=C(C=C2C3=NC4=NON=C4N=C13)OCCC5=CC=CC(C(F)(F)F)=C5
Molecular Formula
C20H11F3N4O3
Molecular Weight
412.32
References & Citations
[1]Lauro G, et al. Furazanopyrazine-based novel promising anticancer agents interfering with the eicosanoid biosynthesis pathways by dual mPGES-1 and sEH inhibition. Eur J Med Chem. 2025 May 5;289:117402.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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