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MPGES1-IN-10

MPGES1-IN-10 (Compound 7d) is a potent microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor with an IC50 value of 1.0 μM. mPGES1-IN-10 is promising for research of chronic inflammation-related diseases and malignancies such as colorectal cancer[1].

Product Specifications

UNSPSC

12352005

Target

PGE synthase

Related Pathways

Immunology/Inflammation

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=C1C2=CC=C(C=C2C3=NC4=NON=C4N=C13)OCCC5=CC=CC(C(F)(F)F)=C5

Molecular Formula

C20H11F3N4O3

Molecular Weight

412.32

References & Citations

[1]Lauro G, et al. Furazanopyrazine-based novel promising anticancer agents interfering with the eicosanoid biosynthesis pathways by dual mPGES-1 and sEH inhibition. Eur J Med Chem. 2025 May 5;289:117402.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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