Lug-15

Lug-15 is a rapid bactericidal agent. Lug-15 exhibits strong antibacterial activity against both Gram-positive and Gram-negative bacteria, including drug-resistant strains. Lug-15 rapidly kills bacteria primarily through membrane disruption and had a very low propensity to induce bacterial resistance. Lug-15 demonstrates low hemolytic toxicity and significant therapeutic potential in various infection models. Lug-15 can be used for research on combating infections caused by multi-drug resistant bacteria[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(N[C@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]1CCCNC(N)=N)=O)=O)[C@@H](NC([C@@H](CCCNC(N)=N)NC([C@@H]2CSC([C@H](C(C)C)NC1=O)N2)=O)=O)CC(C3=C4C=CC=C3)=CN4CC5=CC=C(C6=CC=CC=C6)C=C5

Molecular Formula

C56H81N17O6S

Molecular Weight

1120.42

References & Citations

[1]He Y, et al. Expanding the antimicrobial spectrum of lugdunin: Discovery of multi-cationic derivatives of lugdunin with antimicrobial activity against gram-positive and gram-negative bacteria. Eur J Med Chem. 2025 Dec 5;299:118078.