CDK9-IN-44
CDK9-IN-44 (Compound 7) is a selective CDK9 inhibitor (IC50=7.6 μM) . CDK9-IN-44 inhibits CDK9/cyclin T1 kinase activity, blocking transcriptional elongation, reducing the expression of pro-cancer proteins (such as MCL1, c-MYC), and inducing tumor cell apoptosis. CDK9-IN-44 is promising for research of glioblastoma (GBM) and central nervous system (CNS) disorders[1].
Product Specifications
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer; Neurological Disease
Smiles
OC1=CC=C(C2=COC3=C([C@H]([C@H]4CCCO4)CC(O5)=O)C5=CC(O)=C3C2=O)C=C1
Molecular Formula
C22H18O7
Molecular Weight
394.37
References & Citations
[1]Khan Z R, et al. Computationally Motivated Discovery of Biogenic Compounds with Potent CDK9 Inhibition and In Vitro Effects against Glioblastoma[J]. ACS Chemical Neuroscience, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9
Curated Selection
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