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CDK9-IN-44

CDK9-IN-44 (Compound 7) is a selective CDK9 inhibitor (IC50=7.6 μM) . CDK9-IN-44 inhibits CDK9/cyclin T1 kinase activity, blocking transcriptional elongation, reducing the expression of pro-cancer proteins (such as MCL1, c-MYC), and inducing tumor cell apoptosis. CDK9-IN-44 is promising for research of glioblastoma (GBM) and central nervous system (CNS) disorders[1].

Product Specifications

UNSPSC

12352005

Target

CDK

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer; Neurological Disease

Smiles

OC1=CC=C(C2=COC3=C([C@H]([C@H]4CCCO4)CC(O5)=O)C5=CC(O)=C3C2=O)C=C1

Molecular Formula

C22H18O7

Molecular Weight

394.37

References & Citations

[1]Khan Z R, et al. Computationally Motivated Discovery of Biogenic Compounds with Potent CDK9 Inhibition and In Vitro Effects against Glioblastoma[J]. ACS Chemical Neuroscience, 2025.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK9

Frequently Asked Questions

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