Nav1.7-IN-19

Nav1.7-IN-19 is a potent, selective and orally active Nav1.7 inhibitor with an IC50 of 0.49 μM. Nav1.7-IN-19 shows high selectivity for Nav1.7, with selectivities of 312-fold and 662-fold against Nav1.1 and Nav1.5 in the inactivated state. Nav1.7-IN-19 exhibits weak inhibition on hERG potassium channels. Nav1.7-IN-19 exhibits analgesic effect and can be used for the research of neurological disease[1].

Product Specifications

CAS Number

[3097995-73-5]

UNSPSC

12352005

Target

Potassium Channel; Sodium Channel

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Neurological Disease

Smiles

NC(C(C1CC1)NCCCC2=C(C=CC(Cl)=C2)OC3=C(C=C(C(F)=C3)S(=O)(NC4=NOC=C4)=O)Br)=O

Molecular Formula

C23H23BrClFN4O5S

Molecular Weight

601.87

References & Citations

[1]Wu R, et al. Design, synthesis, structure-activity relationship (SAR) and analgesic effect studies of novel arylsulfonamides as selective Nav1.7 inhibitors. Eur J Med Chem. 2025 Dec 5;299:118069.