TRPA1 agonist-2

TRPA1 agonist-2 (Compound 4B) is an orally active and highly selective TRPA1 channel agonist. TRPA1 agonist-2 triggers calcium influx and stimulates GLP-1 secretion. TRPA1 agonist-2 is promising for research of diabetes, obesity, and related neurodegenerative diseases[1].

Product Specifications

UNSPSC

12352101

Target

TRP Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Metabolic Disease; Neurological Disease

Smiles

O=C(CC1=CC=CC=C1)N2C[N@@](CC=C[C@H]3O2)[C@@]3([H])C4=CC(C(F)(F)F)=CC=C4

Molecular Formula

C21H19F3N2O2

Molecular Weight

388.38

References & Citations

[1]Comparini LM, et al. Synthesis and biological evaluation of N-O heterobicyclic ring systems derived from 1,2-dihydropyridines as novel TRPA1 activators: implication in GLP-1 release and neuroprotection. Eur J Med Chem. 2025 Dec 15;300:118115.