S1PR1 agonist 3
S1PR1 agonist 3 (Compound Y18) is a highly selective S1PR1 receptor agonist (EC50=0.98 nM) . S1PR1 agonist 3 is promising for research of autoimmune diseases such as multiple sclerosis and ulcerative colitis[1].
Product Specifications
CAS Number
[3028594-26-2]
UNSPSC
12352005
Target
LPL Receptor
Related Pathways
GPCR/G Protein
Field of Research
Inflammation/Immunology
Smiles
CC(CC1=C(C=C(C=C1)C2=NOC(C3=CC(Cl)=C(C=C3)CN4CC(C4)C(O)=O)=N2)C(F)(F)F)C
Molecular Formula
C24H23ClF3N3O3
Molecular Weight
493.91
References & Citations
[1]Ye T, et al. Discovery and SAR study of highly selective and potent 1,2,4-oxadiazole-based S1PR1 agonists. Eur J Med Chem. 2025 Dec 15;300:118097.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
S1PR1
Curated Selection
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