BRM/BRG1 ATP-IN-8
BRM/BRG1 ATP-IN-8 (Compound Cpd14) is an orally active BRG1/BRM ATPase domain inhibitor. BRM/BRG1 ATP-IN-8 exerts antitumor effects by disrupting aberrant chromatin remodeling in cancer cells, inducing apoptosis and growth arrest. BRM/BRG1 ATP-IN-8 is promising for research of BRG1/BRM-dependent malignancies, including hematological cancers, prostate cancer, breast cancer, and Ewing's sarcoma[1].
Product Specifications
CAS Number
[2468046-72-0]
UNSPSC
12352005
Target
Epigenetic Reader Domain
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
O=C(C1(CC1)C2=NC=CC(C3=CC=CC(C4=CSC(NC(CNC(C5=CN(S(=O)(C)=O)C=C5)=O)=O)=N4)=C3)=C2)O
Molecular Formula
C26H23N5O6S2
Molecular Weight
565.62
References & Citations
[1]Rishi G. Vaswani, et al. Compounds and uses thereof. WO2020160180A1. 2020-08-06.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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