Anti-TNBC agent-12
Anti-TNBC agent-12 (Compound 23a) is a multi-target antitumor agent targeting HDAC6 (IC50=30.3 nM), DNA, and inducing nitric oxide (NO) release. anti-TNBC agent-12 induces tumor cell apoptosis and G2/M phase cell cycle arrest. anti-TNBC agent-12 is promising for research of triple-negative breast cancer (TNBC) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis; HDAC; NO Synthase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation
Field of Research
Cancer
Smiles
O=S(C1=CC=CC=C1)(C2=[N+]([O-])ON=C2OCCNC(C3=CC(C(C=CC=C4)=C4N5CC6=CC=C(C(NO)=O)C=C6)=C5C=N3)=O)=O
Molecular Formula
C30H24N6O8S
Molecular Weight
628.61
References & Citations
[1]Gao C, et al. Design, synthesis, and biological evaluation of phenylsulfonylfuroxan-β-carboline-hydroxamic acid ternary hybrids for cancer. Eur J Med Chem. 2025 Dec 15;300:118157.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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