SJY26
SJY26 is a PI3K/HDAC dual-target inhibitor with IC50s of 0.59 nM (PI3Kα and PI3Kδ), 2.02 nM (PI3Kγ), 12.69 nM (PI3Kβ) and 114 nM (HDAC1) . SJY26 exhibits potent broad-spectrum anti-proliferative activity, and is particularly sensitive to Jurkat and PC9R cells. SJY26 inhibited the migration of PC9R cells, arrested the cell cycle and induced cell apoptosis. SJY26 reduces AKT phosphorylation, and decreases histone H3 deacetylation (Ac-H3) . SJY26 can be used for the studies of non-small cell lung cancer and leukemia[1].
Product Specifications
UNSPSC
12352005
Target
Akt; HDAC; Histone Methyltransferase; PI3K
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C(C1=CC=NC2=CC=C(C3=CC(NS(=O)(C4=CC=C(F)C=C4F)=O)=C(OC)N=C3)C=C12)NC5=CC=C(C(NC6=CC=CC=C6N)=O)C=C5
Molecular Formula
C35H26F2N6O5S
Molecular Weight
680.68
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
Frequently Asked Questions
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