E3 Ligase Ligand-linker Conjugate 211
E3 Ligase Ligand-linker Conjugate 211 is an E3 ligase ligand-linker conjugate containing a cereblon (CRBN) ligand for E3 ubiquitin ligase and a linker. E3 Ligase Ligand-linker Conjugate 211 can be used to synthesize PROTAC FAK degrader 4.
Product Specifications
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C([C@H]1N(C([C@@H](NC(C[C@H]2CC[C@H](NC(OC(C)(C)C)=O)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3
Molecular Formula
C35H51N5O6S
Molecular Weight
669.87
References & Citations
[1]Liu C, et al. Structure-guided design of a potent focal adhesion kinase (FAK) degrader via ternary complex modeling and molecular dynamics simulation. Bioorg Chem. 2025 Oct;165:109017.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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