IDO1-IN-30

IDO1-IN-30 (Compound (R) -100) is a potent and highly selective IDO1 inhibitor. IDO1-IN-30 has an IC50 of 4.8 nM to IDO1 in SKOV3 cells. IDO1-IN-30 does not show significant cytotoxicity at 25 µM in HepG2 cells. IDO1-IN-30 can eliminate inhibition of CYP450 enzymes (such as 3A4, 2C9, 2D6) . IDO1-IN-30 can be used for research on cancer and inflammatory conditions[1].

Product Specifications

CAS Number

[2581050-29-3]

UNSPSC

12352005

Target

Cytochrome P450; Indoleamine 2,3-Dioxygenase (IDO)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Inflammation/Immunology

Smiles

FC1=C(OC)C=C(F)C(N2N=NC([C@H](O)C3=C(N=CC4=CN=CN34)C5CC5)=C2)=C1

Molecular Formula

C19H16F2N6O2

Molecular Weight

398.37

References & Citations

[1]Cren S, et al. Cellular Potency Optimization of Novel Heme-Binding Imidazo[5,1-b]thiazoles, Imidazo[1,5-a]pyridines and Pyrazines as Potent IDO1 Inhibitors Devoid of Cytochrome P450 Inhibition. J Med Chem. 2025 Oct 9;68 (19) :20130-20153.