PDE1-IN-11

PDE1-IN-11 (Compound 5cc) is an orally active and highly selective PDE1A1 inhibitor. PDE1-IN-11 increases intracellular cAMP and cGMP levels, activating the PKA-CREB and NO-cGMP-PKG signaling pathways, promoting osteoblast differentiation and bone formation, while suppressing osteoclastogenesis and bone resorption. PDE1-IN-11 is promising for research of postmenopausal osteoporosis (PMO) and other bone metabolism disorders[1].

Product Specifications

CAS Number

[86009-41-8]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

O=C1C2=C(SC3=C2CCCC3)N=CN1CCCC

Molecular Formula

C14H18N2OS

Molecular Weight

262.37

References & Citations

[1]Abbasi FM, et al. Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms. J Med Chem. 2025 Oct 9;68 (19) :20536-20560.