LIFR/GPBAR1 modulator 1
LIFR/GPBAR1 modulator 1 is an orally active, potent GPBAR1 agonist (EC50 = 0.2 μM) and LIFR inhibitor (IC50 = 7.9 μM) . LIFR/GPBAR1 modulator 1 upregulates leukaemia inhibitory factor (LIF) -mediated mRNA expression of LIFR and GPBAR1 and significantly reduces the expression of pro-fibrosis markers (COL1A1, ASMA, and TGFβ), and reduces TIMP1 expression and increases MMP9 expression. LIFR/GPBAR1 modulator 1 can be used for the study of human fibrotic disorders[1].
Product Specifications
UNSPSC
12352005
Target
G protein-coupled Bile Acid Receptor 1; MMP; TGF-β Receptor
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; TGF-beta/Smad
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
CC1=CC=C(C#N)C=C1C2=CC=C([C@@H]3C([C@]4([H])[C@@](CCC5=O)([H])[C@]5(C)C3)=C(CC6)C(CC4)=CC6=O)C=C2
Molecular Formula
C32H31NO2
Molecular Weight
461.59
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-9
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