CA IX/GPX4-IN-1

CA IX/GPX4-IN-1 (Compound 22abcb) is a dual targeted inhibitor of CA IX and GPX4 activity. CA IX/GPX4-IN-1 can effectively kill SUM159PT cells (IC50 = 416 nM) by inducing iron death under hypoxic conditions. CA IX/GPX4-IN-1 has an IC50 of 663 nM to CA IX in SUM159PT-CAIX-FL cells. CA IX/GPX4-IN-1 can significantly inhibit tumor growth and can be reversed by ferroptosis inhibitors. CA IX/GPX4-IN-1 can be used for research on breast cancer and other cancers[1].

Product Specifications

UNSPSC

12352005

Target

Carbonic Anhydrase; Ferroptosis; Glutathione Peroxidase

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

C#CC(N(C(C1=CC=C(C=C1)S(N)(=O)=O)C(NCC2=CC=CC=C2)=O)C3=CC(Cl)=C(C=C3)OC)=O

Molecular Formula

C25H22ClN3O5S

Molecular Weight

511.98

References & Citations

[1]Renzi G, et al. Dual inhibition of carbonic anhydrase IX and glutathione peroxidase 4 as a novel strategy for ferroptosis-induced tumor cell death. Eur J Med Chem. 2025 Dec 15;300:118107.