CA IX/GPX4-IN-1
CA IX/GPX4-IN-1 (Compound 22abcb) is a dual targeted inhibitor of CA IX and GPX4 activity. CA IX/GPX4-IN-1 can effectively kill SUM159PT cells (IC50 = 416 nM) by inducing iron death under hypoxic conditions. CA IX/GPX4-IN-1 has an IC50 of 663 nM to CA IX in SUM159PT-CAIX-FL cells. CA IX/GPX4-IN-1 can significantly inhibit tumor growth and can be reversed by ferroptosis inhibitors. CA IX/GPX4-IN-1 can be used for research on breast cancer and other cancers[1].
Product Specifications
UNSPSC
12352005
Target
Carbonic Anhydrase; Ferroptosis; Glutathione Peroxidase
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
C#CC(N(C(C1=CC=C(C=C1)S(N)(=O)=O)C(NCC2=CC=CC=C2)=O)C3=CC(Cl)=C(C=C3)OC)=O
Molecular Formula
C25H22ClN3O5S
Molecular Weight
511.98
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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