IDO1/TDO-IN-10
IDO1/TDO-IN-10 (Compound G-14) is a dual IDO1 (EC50=3.07 μM) and TDO (EC50=9.7 μM) inhibitor. IDO1/TDO-IN-10 inhibits the conversion of tryptophan to kynurenine and modulates immune responses while reducing inflammatory reactions. IDO1/TDO-IN-10 is promising for research of cancers and inflammatory diseases[1].
Product Specifications
UNSPSC
12352005
Target
Indoleamine 2,3-Dioxygenase (IDO)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Inflammation/Immunology
Smiles
COC1=CC=C(C=C1)C2=CSC3=N[C@H](CN23)CCCCNC(NC4=CC=CC(C)=C4)=O
Molecular Formula
C24H28N4O2S
Molecular Weight
436.57
References & Citations
[1]Li Y, et al. Design, Synthesis, and Biological Evaluation of Dual Functional Inhibitors Targeting Indoleamine 2,3-dioxygenase 1 (IDO1) and Tryptophan 2,3-dioxygenase (TDO) . ACS Med Chem Lett. 2025 Sep 26;16 (10) :1979-1985.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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