PROTAC FAK degrader 4

PROTAC FAK degrader 4 (Compound 9C) is an efficient and selective FAK PROTAC degrader. PROTAC FAK degrader 4 has a DC50 of 3.6 nM in MDA-MB-231 cells. PROTAC FAK degrader 4 significantly inhibits tumor cell proliferation, migration, and invasion, and enhances chemotherapy sensitivity to cisplatin (HY-17394) . PROTAC FAK degrader 4 can be used for research on cancer. (Pink: FAK Ligand (HY-43760) ; Blue: VHL Ligand (HY-125845) ; Black: Linker (HY-W208616) ) [1]

Product Specifications

UNSPSC

12352005

Target

FAK; PROTACs

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C([C@H]1N(C([C@@H](NC(C[C@H]2CC[C@H](NC(C3=CC=C(NC4=NC=C(C(F)(F)F)C(OC5=CC=CC(CC6)=C5C6=O)=N4)C(OC)=C3)=O)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7

Molecular Formula

C52H57F3N8O8S

Molecular Weight

1011.12

References & Citations

[1]Liu C, et al. Structure-guided design of a potent focal adhesion kinase (FAK) degrader via ternary complex modeling and molecular dynamics simulation[J]. Bioorganic Chemistry, 2025: 109017.