EP4 receptor antagonist 8
EP4 receptor antagonist 8 is an orally active EP4 antagonist (human EP4 IC50 = 6.40 nM) . EP4 receptor antagonist 8 significantly reduced paw and joint swelling, inflammatory cell infiltration, cartilage damage, pannus formation, and joint bone erosion in arthritis (AIA) mice in a dose-dependent manner. EP4 receptor antagonist 8 can be used for the study of inflammatory pain[1].
Product Specifications
CAS Number
[3068255-86-4]
UNSPSC
12352005
Target
Interleukin Related; Prostaglandin Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C(O)C1=CC=C(CNC(C2=C3C=CC=CC3=NN2CCNC(NC4=CC=C(C#N)C=C4Cl)=O)=O)C=C1
Molecular Formula
C26H21ClN6O4
Molecular Weight
516.94
References & Citations
[1]Xu H, et al. Design and synthesis of Prostanoid EP4 receptor antagonists for treatment of inflammatory pain. Bioorg Chem. 2025 Oct;165:109005.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EP; IL-6
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