RIPK1-IN-34

RIPK1-IN-34 is a selective, brain-penetrant RIPK1 inhibitor (IC50 = 126.70 nM) with almost no inhibitory effect on RIPK3 (IC50 > 10, 000 nM) . RIPK1-IN-34 offers substantial neuroprotection by inhibiting the phosphorylation of RIPK1, RIPK3, and mixed lineage kinase domain-like pseudokinase (MLKL) within the necroptosis pathway. RIPK1-IN-34 shows the neuroprotective effect in a rat middle cerebral artery occlusion (MCAO) model. RIPK1-IN-34 can be used for the study of anti-acute ischemic stroke (AIS) [1].

Product Specifications

CAS Number

[3065634-19-4]

UNSPSC

12352005

Target

Mixed Lineage Kinase; Necroptosis; RIP kinase

Related Pathways

Apoptosis; MAPK/ERK Pathway

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

O=C(C1=C2C=C(C3=CC4=NC(NC(C5CC5)=O)=NN4C=C3)C=CC2=NC(C)=N1)N[C@H](C6=CC=CC=C6)C

Molecular Formula

C28H25N7O2

Molecular Weight

491.54

References & Citations

[1]Su R, et al. Design, synthesis, anti-acute ischemic stroke (AIS) effect of receptor-interacting protein kinase 1 (RIPK1) inhibitors containing quinazoline structure. Bioorg Chem. 2025 Oct;165:109013.