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F0840-0093

F0840-0093 is a highly selective estrogen receptor α (ERα) degrader. F0840-0093 exhibits potent antiproliferative activity against T47D cells with an IC50 value of 4.65 μM. F0840-0093 is promising for research of estrogen receptor-positive (ER+) breast cancer[1].

Product Specifications

CAS Number

503429-76-3

UNSPSC

12352005

Target

Estrogen Receptor/ERR

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Smiles

O=C1C2=CC=CC3=C2C(C(N1CCN4CCN(CC4)C[C@@H](COCC5=CC=C(C=C5)Cl)O)=O)=CC=C3

Molecular Formula

C28H30ClN3O4

Molecular Weight

508.01

References & Citations

[1]Chen M, et al. Identification of novel selective estrogen receptor degraders (SERD) via physics-based and deep-learning-based virtual screening and Bioassys. Bioorg Chem. 2025 Oct;165:109011.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ERα

Frequently Asked Questions

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