Hsp70/FoxM1-IN-1

Hsp70/FoxM1-IN-1 (Compound 7d) is a potent heat shock protein 70 (Hsp70) and Forkhead box M1 (FoxM1) dual inhibitor. Hsp70/FoxM1-IN-1 demonstrates significant antiproliferative and pro-apoptotic effects in multiple solid tumor models (e.g., breast, colorectal cancer), particularly for tumors co-overexpressing Hsp70/FoxM1[1].

Product Specifications

UNSPSC

12352005

Target

DNA/RNA Synthesis; HSP

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

BrC1=C2N=C(SC2=CC(S(=O)(NC(C3=CC=CC=C3)=O)=O)=C1)SCC4=CC=C(C=C4)Cl

Molecular Formula

C21H14BrClN2O3S3

Molecular Weight

553.90

References & Citations

[1]Alimardan Z, et al. Design, synthesis, and anticancer evaluation of benzimidazole and benzothiazole derivatives targeting Hsp70 and FoxM1. Bioorg Med Chem Lett. 2025 Sep 10;130:130401.