Hsp70/FoxM1-IN-1
Hsp70/FoxM1-IN-1 (Compound 7d) is a potent heat shock protein 70 (Hsp70) and Forkhead box M1 (FoxM1) dual inhibitor. Hsp70/FoxM1-IN-1 demonstrates significant antiproliferative and pro-apoptotic effects in multiple solid tumor models (e.g., breast, colorectal cancer), particularly for tumors co-overexpressing Hsp70/FoxM1[1].
Product Specifications
UNSPSC
12352005
Target
DNA/RNA Synthesis; HSP
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
BrC1=C2N=C(SC2=CC(S(=O)(NC(C3=CC=CC=C3)=O)=O)=C1)SCC4=CC=C(C=C4)Cl
Molecular Formula
C21H14BrClN2O3S3
Molecular Weight
553.90
References & Citations
[1]Alimardan Z, et al. Design, synthesis, and anticancer evaluation of benzimidazole and benzothiazole derivatives targeting Hsp70 and FoxM1. Bioorg Med Chem Lett. 2025 Sep 10;130:130401.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP70
Curated Selection
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