LDHA-IN-10

LDHA-IN-10 (Compound HP19) is a Lactate Dehydrogenase-A (LDHA) inhibitor with an IC50 value of 5.2 μM. LDHA-IN-10 reduces lactate production and ATP levels, inhibiting the proliferation of pancreatic cancer cell line PANC-1. LDHA-IN-10 induces G1/S cell cycle arrest and promotes apoptosis. LDHA-IN-10 is promising for research of pancreatic ductal adenocarcinoma (PDAC) [1].

Product Specifications

UNSPSC

12352005

Target

Lactate Dehydrogenase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

O=C(C1(C2=CC=C(C3=NC4=CC=CC=C4O3)C=C2)C)N=C(SCC5=CC=C(F)C=C5)NC1=O

Molecular Formula

C25H18FN3O3S

Molecular Weight

459.49

References & Citations

[1]Sharma H, et al. Synthesis, molecular modeling, biological and pharmacokinetic evaluation of hydroxy pyrimidinones and pyrimidinediones as novel LDHA inhibitors. Eur J Med Chem. 2025 Dec 15;300:118156.