BRK/PTK6-IN-1
BRK/PTK6-IN-1 (Compound 51) is a highly efficient and selective BRK inhibitor (IC50 = 3.37 nM, Kd = 44 nM) . BRK/PTK6-IN-1 can reduce MMP-9 protein expression and inhibit IGF-1 induced AKT phosphorylation in MDA-MB-231 cells. BRK/PTK6-IN-1 significantly inhibits migration, invasion, and colony formation but does not affect cell proliferation. BRK/PTK6-IN-1 is often used in the research of breast cancer and other cancers[1].
Product Specifications
UNSPSC
12352005
Target
Akt; BRK; MMP
Related Pathways
Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
NC1=C2C(N(C)N=C2C3=C(F)C=CC(O)=C3)=NC=N1
Molecular Formula
C12H10FN5O
Molecular Weight
259.24
References & Citations
[1]Acharya B, et al. Discovery of novel 1H-pyrazolo[3,4-d]pyrimidine derivatives as BRK/PTK6 inhibitors. Eur J Med Chem. 2025 Dec 15;300:118145.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt; MMP-9
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