UBA5-IN-2
UBA5-IN-2 (Compound 50) is a potent ubiquitin-like modifier activating enzyme 5 (UBA5) inhibitor (IC50=0.063 μM) . UBA5-IN-2 is promising for research of cancers and protein homeostasis-related diseases[1].
Product Specifications
UNSPSC
12352005
Target
E1/E2/E3 Enzyme
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Metabolic Disease
Smiles
CN(C(CNC(C1=C2C=CC=NC2=CC=C1)=O)=O)[C@H]3CCCN(C4=C(C=C(C5=C4C(C)=C(N5C)C)C(N[C@@H]6COCC[C@H]6O)=O)F)C3
Molecular Formula
C35H41FN6O5
Molecular Weight
644.74
References & Citations
[1]Mignone JJ, et al. Discovery of Potent and Selective Reversible Ubiquitin-Like Modifier Activating Enzyme 5 Inhibitors Targeting the UFMylation Pathway. J Med Chem. 2025 Oct 9;68 (19) :20827-20845.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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