Antileishmanial agent-36

Antileishmanial agent-36 (compound 4f) is an indole-dihydropyrimidinone derivative with anti-leishmanial activity. Antileishmanial agent-36 induces reactive oxygen species (ROS) -mediated mitochondrial dysfunction and apoptosis. Antileishmanial agent-36 exhibits potent activity against L. donovani (IC50 =4.54 μM) with low cytotoxicity against J774.1 macrophage. Antileishmanial agent-36 clears the parasite burden in a visceral leishmaniasis (VL) model. Antileishmanial agent-36 can be used for VL research[1].

Product Specifications

CAS Number

[3086122-36-0]

UNSPSC

12352005

Target

Apoptosis; Parasite; Reactive Oxygen Species (ROS)

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Infection

Smiles

O=C1NC(C)=C(C(C2=CC=C(N(C)C)C=C2)N1)C(NCCC3=CNC4=C3C=CC=C4)=O

Molecular Formula

C24H27N5O2

Molecular Weight

417.50

References & Citations

[1]Mishra G, et al. Exploring indole-dihydropyrimidinone derivatives: Design, synthesis, biological assessment, SAR analysis, and evaluation of mode of action in experimental visceral leishmaniasis. Eur J Med Chem. 2025 Sep 5;293:117667.